Figure 4 | Scientific Reports

Figure 4

From: Genome-wide profiling of DNA methylation provides insights into epigenetic regulation of fungal development in a plant pathogenic fungus, Magnaporthe oryzae

Figure 4

Dynamics of DNA methylation in the genome of M. oryzae.

(A) Density of mCs in different genomic features, counted in total length of corresponding feature (multiplied by 104). Up and Down indicate 1.5 kb upstream and 1 kb downstream regions of annotated genes, respectively. (B) Number of genes having DNA methylation in upstream, downstream and coding sequences during development. To avoid over-counting issue, assignment of mC sites to genomic categories was done based on proximity to genes near it. For example, if a mC site is at downstream of locus A and at the same time upstream of locus B but closer to locus B, then this site was counted as upstream methylation of locus B. (C) A representative region of chromosome 1 (indicated by arrows in Fig. 1) showing dynamic changes in DNA methylation during development. (D) Density of mCs in and around genes associated with DNA methyaltion during fungal development. Genes were aligned at the 5′ end (left dashed line) or the 3′ end (right dashed line) and number of mCs in each 50 bp interval was plotted across genic region.

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