Figure 1 | Scientific Reports

Figure 1

From: Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle

Figure 1

Chemotherapy treatment causes sustained impairment of whole animal and muscle growth.

(A) Changes in body weight over time in control vs. chemotherapy treated animals. Arrows indicate timings of each cycle of chemotherapy. (B) Representative photographs of control (left) and treated (right) mice taken at the end of our long-term chemotherapy protocol. Gastrocnemius muscle weights obtained in control and treated animals in the early (C) and late (D) chemotherapy treatment groups. (E) Representative triple MHC labeling (MHCI: blue; MHCIIa: red; MHCIIx: purple; MHCIIb: green) performed on gastrocnemius muscle serial cross sections obtained in control (images on the left) and treated (images on the right) mice in the late group. Scale bars: 50 μm. (F) Quantification of gastrocnemius muscle fiber size in control and treated mice. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01.

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