Figure 5 | Scientific Reports

Figure 5

From: MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRγ*

Figure 5

Forced expression of miR-320a re-sensitizes TamR breast cancer cells to tamoxifen in xenografts.

(a). Forced expression of miR-320a in MCF-7-TamR cells was detected by real-time PCR. (b). Tumor growth curves derived from MCF-7-TamR and parental cells transplanted in nude mice in the presence or absence of tamoxifen supplement. Numerical data was expressed as mean ± SD of 6 mice. (c), Ki-67 staining of sections was used to examine the proliferation of the tumors formed. The quantified result was shown on the right. (d). The expression levels of miR-320a in the xenograft tumors were examined by real-time PCR. *P < 0.05, **P < 0.01, ***P < 0.001.

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