Figure 4 | Scientific Reports

Figure 4

From: Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans

Figure 4

In vivo virulence assay of candidate genes using a wax moth model system.

Each larva (15 per group) was infected with 800,000 Cryptococcus cells and incubated at either 30°C or 37°C. The percent survival (%) was monitored for two weeks post-infection. The results were as follows: p = 0.0337 for CMO18 vs. the cdc2801Δ (CNAG_00415) mutant at 37°C; p = 0.0064 for CMO18 vs. the pdk1Δ (CNAG_02915) mutant at 37°C; p = 0.0269 for CMO18 vs. the snf1Δ (CNAG_06552) mutant at 37°C; p = 0.0394 for CMO18 vs. CNAG_06845 at 30°C; p = 0.0021 for CMO18 vs. the kin4Δ (CNAG_05558) mutant at 30°C; p = 0.007 and p = 0.0155 for CMO18 vs. CNAG_03811 at 30°C or 37°C, respectively.

Back to article page