Figure 5 | Scientific Reports

Figure 5

From: Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans

Figure 5

Novel genes for antifungal drug resistance.

(A) The antifungal drug resistance test. Cells grown to the mid-logarithmic phase were 10-fold serially diluted (1 to 104) and spotted on YPD medium containing the indicated concentration of azole drugs (fluconazole: 16 μg/ml; itraconazole: 0.06 μg/mL; and ketoconazole: 0.25 μg/mL) or amphotericin B (1.2 μg/mL) and further incubated at 30°C for the antifungal drug resistance assay. (B) The neighbors of six novel drug resistance genes are enriched for four biological processes: sterol biosynthetic process, response to drug, transmembrane transport and cell wall organization and biogenesis. The genes for the four enriched processes show high modularity in CryptoNet.

Back to article page