Figure 1 | Scientific Reports

Figure 1

From: New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

Figure 1

Distribution of potency by chemical box (Leishmania donovani in pink, Trypanosoma brucei in blue and T. cruzi in green) and parasite.

Left panels: 3D scatter plot of pIC50 values for each compound against L. donovani (Ld pIC50, as inhibition of amastigotes per macrophage readout from imaging assay), T. cruzi (Tc pIC50, as inhibition of amastigotes per cell readout from imaging assay) and T. brucei (Tb pIC50, as inhibition of FLINT from fluorescent assay). Right panels: Distribution of potency for all compounds of each of the three chemical boxes (~200 compounds distributed into 40 potency bins).

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