Figure 2 | Scientific Reports

Figure 2

From: New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

Figure 2

Histogram of assignment of positive compounds based on historical assay data and homology of human protein targets to kinetoplastid genomes.

Histograms are clustered by assays for Leishmania donovani (Ld), Trypanosoma brucei (Tb) and T. cruzi (Tc). The threshold above which compound efficacy against specific human targets was considered significant was defined as pIC50 ≥ 5 for inhibition or antagonist assays and pEC50 ≥ 5 for agonist, activation or modulator assays (i.e. overall pXC50 ≥ 5). Kinetoplastid homologs to human proteins were assigned based on BLASTP E-values ≤ 1.0e–05. Some compounds met the criteria for multiple human proteins (cross-hatched bars) while some kinetoplastid proteins had homology to multiple human proteins (solid bars).

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