Table 1 Characteristics of included studies

From: Diagnostic accuracy of PLA2R autoantibodies and glomerular staining for the differentiation of idiopathic and secondary membranous nephropathy: an updated meta-analysis

Study, Year(Reference)

Research type

Publication

Area

Agea

Sex (male/female)

Samplesize

Sample type

Proteinuria (g/day)ab

Serum Creatinine (mg/dl)ab

TreatmentWith ISa

Time from biopsy(Mo.)

Hoxha et al. 20118

Prospective

Full txt

Germany

NA

NA

117

Serum

“nonNS-NS”

NA

55%&29%

NA

McGettigan et al. 201217

Retrospective

Abstract

Australia

NA

NA

32

Serum

NA

NA

NA

NA

Qin et al. 20119

Prospective

Full txt

China

41

61/35c

106

Serum

3.51–13.5&3.51–14.43

0.4–3.92&0.22–1.46

None

0

Oh et al. 201310

Prospective

Full txt

Korea

54.7

51/49c

109

Serum

3.17–9.86

0.91 ± 0.35

None

0

Kimura et al. 201218

Retrospective

Abstract

Japan

NA

NA

36

Serum

NA

NA

NA

NA

Ardalan et al. 201311

Retrospective

Full txt

Iran

34

13/12

25

Serum

0.7–4.9

1.0–9.5

all

7–71

Hoxha et al. 201212

Prospective

Full txt

Germany

56.5&57.7

64/24

88

Serum + Tissue

0.1–33&0.77–22.7

0.5–5.28&0.7–2.7

None

0–11

Bajcsi et al. 201319

Retrospective

Abstract

Hungary

NA

NA

6

Serum

NA

NA

NA

0

Svobodova et al. 201313

Retrospective

Full txt

Czech

52.6

NA

84

Serum + Tissue

10.1 ± 7.6

1.22 ± 0.58

None

0

Svobodova et al. 201220

Retrospective

Abstract

Czech

NA

NA

28

Serum

8.6 ± 3.6&9.3 ± 8.3

NA

None

0

Schonermarck et al. 201221

Retrospective

Abstract

Germany

NA

NA

34

Serum

NA

NA

NA

NA

Beck et al. 20097

Retrospective

Full txt

USA

47&38

28/17

45

Serum

0.6–14&0.3–9.1

0.4–3.1&0.5–0.8

34%&43%

0–132

Kanigicherla et al. 201314

Retrospective

Full txt

UK

54

64/26c

109

Serum

5.9–12.8

0.86–1.37

30%

NA

Larsen et al. 201216

Retrospective

Full txt

USA

57.5&47.4

89/76

165

Tissue

7.3 ± 5&5.7 ± 4.7

1.4 ± 0.9 &1.7 ± 1.7

NA

0

Barrett et al. 201415

Retrospective

Full txt

USA

69

3/4

7

Tissue

1–11&1.5–9

1.2–4.1&1.1–5.7

all

0

Medrano et al. 201422

Retrospective

Full txt

Spain

52.3

41/23

64

Serum + Tissue

8.6–15&7.55–11

1.1 ± 0.55&1 ± 0.27

NA

NA

Meneses et al. 201423

Retrospective

Abstract

Portugal

NA

NA

38

Serum

NA

NA

NA

NA

Brenchley et al. 201424

Retrospective

Abstract

UK

NA

NA

26

Serum

NA

NA

NA

NA

Gasim et al. 201425

Retrospective

Abstract

USA

54

21/20

41

Tissue

NA

NA

NA

NA

  1. Abbreviations: NS, nephrotic syndrome; IS, immunosuppressor; NA, not available; Mo, month.
  2. aA ampersand separating values denotes data from idiopathic membranous nephropathy and secondary membranous nephropathy respectively.
  3. bdata were expressed as an statistic range or mean ± standard deviation.
  4. cdata were only provided from patients with idiopathic membranous nephropathy.