Table 3 Pooled diagnostic accuracy for differentiation iMN from sMN

From: Diagnostic accuracy of PLA2R autoantibodies and glomerular staining for the differentiation of idiopathic and secondary membranous nephropathy: an updated meta-analysis

PLA2R

No. of studies

Pooled Sensitivity (95%CI)

Pooled Specificity (95%CI)

DOR (95% CI)

AUROC (95% CI)

I2 (%)

Likelihood Ratio (95% CI)

Pre-test

Post-test(+)

Post-test(−)

Positive

Negative

Serological testsa

16

0.68(0.61–0.74)

0.97(0.85–1.00)

73.75(12.56–432.96)

0.82(0.78–0.85)

83.70

24.48(4.21–142.43)

0.33(0.28–0.40)

0.25

0.89

0.10

Serological testsb

5

0.78(0.71–0.84)

0.82(0.61–0.93)

16.54(4.82–56.78)

0.82(0.78–0.85)

0.00

4.38(1.74–10.79)

0.26(0.18–0.39)

0.25

0.59

0.08

Biopsy tests

6

0.78(0.72–0.83)

0.91(0.75–0.97)

34.70(9.93–121.30)

0.84(0.81–0.87)

0.00

8.40(2.87–24.64)

0.24(0.18–0.32)

0.25

0.74

0.07

  1. a: data from serum anti-PLA2R in patients of included articles.
  2. b: data from serum anti-PLA2R in patients of >3.5 g/24 h proteinuria before immunosuppressor treatment at the time of renal biopsy.
  3. Abbreviations: I2, chi-square; CI, confidence interval; DOR, diagnostic odds ratio; AUROC, area under the receiver operating characteristic curve.
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