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Figure 1

From: Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits

Figure 1

Osteonecrosis Lesion Differentiation and Classification at 2 weeks and 4 weeks Post-administration.

(A). Appositional bone formation (dashed arrows) with osteoblasts (OB) around the necrotic bone (ON), defined as ‘reparative osteogenesis’. (B). Eroded bone surface (solid arrows) with osteoclasts (OC) around the necrotic bone (ON) during fibrous tissue creep (dashed arrow), defined as ‘destructive repair’. (C & D). The incidence of the destructive repair in the Anti-VEGF Group, Src-Inhibition Group and Supplement & Inhibition Group was all lower than that in the Control Group, whereas it was higher in the VEGF-Supplement Group when compared to the Control Group at 2 weeks and 4 weeks Post-administration. N = 8 for 2 Weeks Post-administration, N = 15 for 4 Week Post-administration, Fisher's exact probability test, *P < 0.05 vs Control.

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