Figure 4
From: Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications
Dose-dependent study of different drugs on the cardiac MPS.
(a) Isoproterenol causes a dose-dependent increase in beat rate and an EC50 value of 315 nM. (b) Verapamil induces a dose-dependent decrease in beat rate with incidences of arrhythmia observed at higher concentrations and an IC50 value of 950 nM. (c, d) Metoprolol and E4031 induce a dose-dependent decrease in beat rate with IC50 values of 2.3 μM and 1.9 nM respectively. Grey areas indicate unbound estimated therapeutic plasma concentration in patients (ETPC)28,35. Note there is not an ETPC highlighted for E-4031 because the drug is used solely for research purposes and only one clinical trial was conducted. Error bars indicate mean ± S.D.
