Table 1 Cohort of drugs from different classes that have been tested in our cardiac MPS

From: Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

Class

Drug

Pharmacology

Average ETPCunbound

Safety Margin = IC50/Average ETPCunbound

Ca2+ channel & hERG blocker

Verapamil

IC50 = 950 nM

53 nM

18

β-adrenergic agonist

Isoproterenol

EC50 = 315 nM

1.75 nM

180

β-adrenergic antagonist

Metoprolol

IC50 = 244 μM

2.3 μM

106

hERG blocker

E-4031

IC50 = 392 nM

1.9 nM

206

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