Figure 6 | Scientific Reports

Figure 6

From: Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway

Figure 6

Antho 50 affects p-Bad and Bcl-2 proteins through a ROS-dependent mechanism.

B CLL cells were exposed to either PEG-catalase (500 U/mL), catalase (500 U/mL), or SOD (500 U/mL) for 30 min before the addition of Antho 50 (75 μg/mL) for the indicated times. The expression of p-Bad and Bcl-2 was studied using Western blot and their expression levels were analyzed by densitometry and represented as percentage compared with control (Ctr). The control represents untreated cells harvested at the latest time point. The data are representative of four CLL patients.

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