Figure 7 | Scientific Reports

Figure 7

From: Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway

Figure 7

Antho 50 affects cleaved caspase 3 and UHRF1 proteins through a ROS-dependent mechanism.

B CLL cells were exposed to either PEG-catalase (500 U/mL), catalase (500 U/mL), or SOD (500 U/mL) for 30 min before the addition of Antho 50 (75 μg/mL) for the indicated times. The expression of cleaved caspase 3 and UHRF1 was studied using Western blot and their expression levels were analyzed by densitometry and represented as percentage compared with control (Ctr). The control represents untreated cells harvested at 6 h. The data are representative of three CLL patients.

Back to article page