Figure 1 | Scientific Reports

Figure 1

From: Allostery through protein-induced DNA bubbles

Figure 1

TFAM-DNA interaction model.

(a) Schematic representation of the TFAM structure. Note the orientation of TFAM on DNA relatively to HSP1 and LSP promoters. (b) Illustration of TFAM-DNA complex and the resulting local unwinding of the double helix at the end of each HMG Box domain. (c) Representation of the DNA-TFAM interaction potential (see Eq. 2). V1 suppresses the double strand at the core of the TFAM-DNA complex and V2 unwinds it at the two ends of the TFAM.

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