Figure 3
TFAM diffusion and oligomerization on DNA.
(a) Langevin dynamics of 10 TFAMs diffusing in a 0.33 μm long mtDNA. Green color shows the envelope and position of TFAMs as a function of time. Red areas correspond to large hinges induced by oligomerization. Spontaneous aggregation and dissociation of TFAM oligomers as well as entrapment of oligomers/monomers due to sequence specificity are present in this example. (b) Monte Carlo simulation of 20 TFAMs interacting with the average PMF presented in Figure 2. Picture is similar to a, but for considerably larger length and time scales, thus allowing direct comparison with experiments17,24.
