Figure 1 | Scientific Reports

Figure 1

From: An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway

Figure 1

2-Cl-IB-MECA attenuates clinical activity of DSS-induced murine colitis.

(A) DSS-induced weight loss is ameliorated by 2-Cl-IB-MECA administration. In animals receiving 5% DSS, maximum weight loss was significantly reduced to 17% (with 2-Cl-IB-MECA treatment) from 28% (with DMSO treatment). After 9 days, 2-Cl-IB-MECA-treated mice recovered faster. ANOVA between all groups, P < 0.01; post-tests, 5% DSS + 2-Cl-IB-MECA versus 5% DSS + DMSO, P < 0.01; 5% DSS + DMSO versus 5% DSS, P > 0.05. 2-Cl-IB-MECA administration reduced diarrhea and fecal occult blood. (B) 5% DSS colitis animals mostly develop diarrhea on days 7–9, whereas 2-Cl-IB-MECA-treated animals induced with 5% DSS exhibited reduced diarrhea (**chi-square test comparing incidence of diarrhea between vehicle-treated and 2-Cl-IB-MECA-treated mice induced with 5% DSS, P < 0.01). (C) 2-Cl-IB-MECA-treated mice have a lower incidence of occult blood than did vehicle-treated animals on day 9 after 5% DSS induction (*chi-square test, DMSO versus 2-Cl-IB-MECA, P < 0.05).

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