Figure 5 | Scientific Reports

Figure 5

From: Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi

Figure 5

PMT-dependent inhibition of growth and PC biosynthesis by amodiaquine and NSC158011.

(A–C): Growth curves of pem1Δpem2Δ-pYES2.1-PkPMT (A), pem1Δpem2Δ-pYES2.1-PvPMT (B), or Wild Type-pYES2.1- (C) strains grown in minimal medium containing 4% galactose and 1 mM ethanolamine in the presence or absence of 100 μM choline and 100 μM amodiaquine (AQ) as indicated. Growth curves of pem1Δpem2Δ-pYES2.1-PkPMT (D), pem1Δpem2Δ-pYES2.1-PvPMT (E), or Wild Type-pYES2.1- (F) strains maintained in minimal medium containing 4% galactose and 1 mM ethanolamine in the presence or absence of 100 μM choline and 10 μM NSC158011.

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