Figure 7 | Scientific Reports

Figure 7

From: Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi

Figure 7

An overview of the crystal structure of PvPMT in complex with SAM and PO4 (PDB code: 4IV0).

(A) Folds of PvPMT shown as cartoon (green) with SAM (gray) and PO4 (red) in stick representation. (B) Omit σA-weighted mFo-Fc electron density map for SAM bound to PvPMT active site (contour level at 1.0 σ). (C) Stereo view of active site residues of PvPMT (green) interacting with SAM (gray) and PO4 (red). Water is represented as spheres (red). Hydrogen bonds (<3.5 Å) are indicated as dashed lines.

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