Figure 3 | Scientific Reports

Figure 3

From: PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Figure 3

PERK silencing decreased p-AKT in glioma cells under ER stress.

U87 and U251 cells were transfected with NC or PERK shRNA and 48 hours later the cells were treated by TM (ER stress inducer) for another 48 h. Western-blot analyses were performed to detect p-AKT (Ser473), AKT, PERK, p-PERK, p-EIF2α and EIF2α protein expression. Statistical analysis of p-AKT/AKT was derived from 3 independent experiments which were run under same conditions. **, P < 0.01.

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