Figure 8 | Scientific Reports

Figure 8

From: PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Figure 8

PERK silencing suppressed glioma growth in vivo.

(a) lenti-PERK shRNA and lenti-NC U87 cells were subcutaneously injected into left and right hips of BALB/c nude female mice (n = 4). The typical images of mice bearing glioma were pictured 4 weeks later. (b) Tumor volumes were measured once a week and data was presented as mean ± SEM. *, P < 0.05. (c) Westernblot analysis of total HK2, p-AKT, p-PERK and p-EIF2α in indicated cells or glioma tissues respectively. (d) Statistical analysis of p-AKT/AKT was derived from 4 independent experiments. *, P < 0.05, **, P < 0.01. (e) Westernblot analyses of mitochondrial HK2 protein expression in indicated cells or glioma tissues respectively. Statistical analysis of mitochondrial HK2 protein expression was derived from 4 independent experiments. **, P < 0.01.

Back to article page