Figure 4 | Scientific Reports

Figure 4

From: Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers

Figure 4

SchB treatment affects SREBP-1 expressions in long-term HFD-fed mice.

Representative western blotting showing (A) expression of mature sterol regulatory element binding protein-1 (mSREBP-1), (B) ratio of precursor to mature SREBP-1 and (I) tumor necrosis factor (TNF-α) in HFD-fed mouse livers. Bar charts showing the mean ± SE (n = 4 mice in each group), *p < 0.05. (C) Protein expression of mature SREBP-1 (mSREBP-1) and (D) relative mRNA expression of SREBP-1 in FFA-treated MIHA cells. Protein expressions of (E, G) mSREBP-1 and (F) FAS upon TNF-α challenges and (H) protein expressions of TNF-α in FFA-treated MIHA cells. Full length blots were shown in Supplementary S7. Bar charts showing the mean ± SE (n = 3 independent experiments), *p < 0.05. FFA: FFA-treated vehicle control MIHA cells; FFA+SchB: FFA-treated SchB-treated MIHA cells.

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