Figure 2
Sod2 deficiency in osteocytes induces osteoporosis in an age-dependent manner.
(a) 3D-μCT images of coronal sections of the femurs of the Sod2ot/ot and wild-type littermates at 3, 5 and 12 months of age (n = 5–6 each group). (b) The femoral BMD of the Sod2ot/ot and wild-type males at 3, 5 and 12 months of age (n = 5 each group). (c–g) The morphological parameters for the trabecular and cortical regions of the femurs at 3, 5 and 12 months of age measured according to μCT (n = 5–6 each group). (c) The bone volume per total volume (BV/TV), (d) cortical thickness (Ct.Th), (e) trabecular number (Tb.N), (f) trabecular separation (Tb.Sp) and (g) trabecular thickness (Tb.Th). *p < 0.05. The error bars indicate the SD.
