Table 2 Univariable and multivariable Cox regression analyses for OS in 1,031 patients treated for HCC

From: A Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma

Variables

Univariate analysis

Multivariate analysis

HR

95% CI

p value

HR

95% CI

p value

Age (yrs)

1.002

0.995–1.009

0.579

   

Gender (male vs. female)

1.170

0.911–1.504

0.219

   

TBIL (μmol/L)

1.005

1.002–1.008

<0.001

1.005

1.002–1.008

0.001

ALB (g/L)

0.947

0.928–0.966

<0.001

0.966

0.947–0.986

0.001

ALT (U/L)

1.001

0.999–1.002

0.268

   

PT (second)

1.176

1.106–1.251

<0.001

1.165

1.095–1.239

<0.001

Log (AFP)

1.204

1.138–1.273

<0.001

1.096

1.033–1.163

0.002

HBsAg (positive vs. negative)

1.062

0.852–1.323

0.593

   

Tumor size (cm)

1.076

1.057–1.095

<0.001

1.056

1.036–1.076

<0.001

Tumor number (multiple vs. single)

1.894

1.593–2.253

<0.001

1.540

1.286–1.844

<0.001

Tumor capsule (complete vs. incomplete)

0.589

0.507–0.706

<0.001

0.716

0.604–0.849

<0.001

Microvascular invasion (yes vs. no)

1.122

0.846–1.488

0.423

   

Pathological grades

      

 II vs. I

1.643

1.253–2.153

<0.001

1.204

0.953–1.522

0.119

 III vs. I

2.851

2.370–3.344

<0.001

1.535

1.177–2.002

0.002

  1. AFP, alpha-fetoprotein; ALB, albumin; ALT, alanine aminotransferase; CI, confidence interval; HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; HR, hazard ratio; PT, prothrombin time; TBIL, total bilirubin.
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