Figure 1
From: CASP7 variants modify susceptibility to cervical cancer in Chinesewomen
High-order interaction analyses for the four CASP7 SNPs.
(A) The best multifactor dimensionality reduction interactionmodels. The multi-locus model with maximum cross-validation consistency andminimum prediction error rate is indicated in bold. (B) Interaction dendrogram.The color indicates the strength of the dependence: green is weak and redis strong. (C) Interaction entropy graph. Each SNP is shown in a box withthe percent of entropy (main effect). Two-way interactions between SNPs aredepicted as an arrow accompanied by a percent of entropy (interaction effect).In the interaction graph, rs4353229 alone eliminates 0.13% of class entropyand has the largest univariate effect. Only small percentages of entropy wereexplained by rs12247479 (0.04%) or rs1127687 (0.03%) when considered independently,while a large percentage of entropy was explained by their pairwise interactions(0.11%), indicating a synergistic interaction. (D) Classification and regressiontree. Terminal nodes are thick bordered. W, wild type genotype; V, variantgenotype; TN, terminal node; #, P value <0.05.
