Table 1 Associations of CASP7genotypes with the risk of cervical cancer
From: CASP7 variants modify susceptibility to cervical cancer in Chinesewomen
Variants Genotypes | Cases (N = 1,486) | Controls (N = 1,301) | P a | Crude OR (95% CI) | P | Adjusted OR (95%CI)a | P b |
|---|---|---|---|---|---|---|---|
CASP7- rs4353229 | HWE = 0.566 | ||||||
CC | 236 (15.9) | 226 (17.4) | 1.00 | 1.00 | |||
CT | 708 (47.6) | 653 (50.2) | 1.04 (0.84–1.28) | 0.727 | 1.05 (0.84–1.31) | 0.687 | |
TT | 542 (36.5) | 422 (32.4) | 1.23 (0.99–1.54) | 0.068 | 1.19 (0.94–1.50) | 0.154 | |
Additive model | 0.077 | 1.12 (1.01–1.25) | 0.036 | 1.10 (0.98–1.23) | 0.110 | ||
Dominant model | 0.291 | 1.11 (0.91–1.36) | 0.291 | 1.10 (0.89–1.36) | 0.367 | ||
Recessive model | 0.025 | 1.20 (1.02–1.40) | 0.026 | 1.15 (0.97–1.35) | 0.106 | ||
CASP7- rs12247479 | HWE = 0.298 | ||||||
GG | 1,153 (77.6) | 1,023 (78.6) | 1.00 | 1.00 | |||
AG | 315 (21.2) | 257 (19.8) | 1.09 (0.90–1.31) | 0.375 | 1.08 (0.89–1.31) | 0.431 | |
AA | 18 (1.2) | 21 (1.6) | 0.76 (0.40–1.43) | 0.397 | 0.69 (0.35–1.39) | 0.301 | |
Additive model | 0.448 | 1.03 (0.88–1.22) | 0.712 | 1.02 (0.86–1.21) | 0.830 | ||
Dominant model | 0.508 | 1.06 (0.89–1.27) | 0.508 | 1.05 (0.87–1.27) | 0.593 | ||
Recessive model | 0.366 | 0.75 (0.40–1.41) | 0.367 | 0.68 (0.34–1.36) | 0.279 | ||
CASP7- rs10787498 | HWE = 0.034 | ||||||
TT | 929 (62.5) | 857 (65.9) | 1.00 | 1.00 | |||
GT | 493 (33.2) | 383 (29.4) | 1.19 (1.01–1.40) | 0.038 | 1.19 (1.00–1.41) | 0.045 | |
GG | 64 (4.3) | 61 (4.7) | 0.97 (0.67–1.39) | 0.860 | 0.91 (0.62–1.34) | 0.637 | |
Additive model | 0.104 | 1.09 (0.96–1.25) | 0.173 | 1.08 (0.94–1.24) | 0.257 | ||
Dominant model | 0.066 | 1.16 (0.99–1.35) | 0.066 | 1.15 (0.98–1.36) | 0.090 | ||
Recessive model | 0.627 | 0.92 (0.64–1.31) | 0.626 | 0.86 (0.59–1.26) | 0.438 | ||
CASP7- rs1127687 | HWE = 0.278 | ||||||
GG | 896 (60.3) | 804 (61.8) | 1.00 | 1.00 | |||
AG | 518 (34.9) | 429 (33.0) | 1.08 (0.92–1.27) | 0.325 | 1.08 (0.91–1.28) | 0.371 | |
AA | 72 (4.9) | 68 (5.2) | 0.95 (0.67–1.34) | 0.771 | 0.89 (0.61–1.28) | 0.512 | |
Additive model | 0.554 | 1.03 (0.91–1.17) | 0.616 | 1.02 (0.89–1.16) | 0.829 | ||
Dominant model | 0.417 | 1.07 (0.91–1.24) | 0.418 | 1.05 (0.90–1.24) | 0.533 | ||
Recessive model | 0.646 | 0.92 (0.66–1.30) | 0.645 | 0.86 (0.60–1.24) | 0.416 | ||
Combined effects of four putativerisk genotypes by the dominant genetic model | |||||||
0 | 235 (15.8) | 223 (17.1) | 0.078 | 1.00 | 1.00 | ||
1 | 264 (17.8) | 227 (17.5) | 1.10 (0.86–1.42) | 0.449 | 1.09 (0.83–1.42) | 0.541 | |
2 | 587 (39.5) | 537 (41.3) | 1.04 (0.84–1.29) | 0.741 | 1.03 (0.82–1.30) | 0.784 | |
3 | 308 (20.7) | 263 (20.2) | 1.11 (0.87–1.42) | 0.401 | 1.10 (0.85–1.42) | 0.478 | |
4 | 92 (6.2) | 51 (3.9) | 1.71 (1.16–2.52) | 0.007 | 1.62 (1.08–2.43) | 0.020 | |
Ptrend = 0.076 | Ptrenda= 0.127 | ||||||
0–3 | 1,394 (93.8) | 1,250 (96.1) | 0.007 | 1.00 | 1.00 | ||
4 | 92 (6.2) | 51 (3.9) | 1.62 (1.14–2.30) | 0.007 | 1.54 (1.07–2.22) | 0.021 |
