Table 2 Locus-locus jointeffects in associations between CASP7 genotypes and cervical cancerrisk
From: CASP7 variants modify susceptibility to cervical cancer in Chinesewomen
Locus-locus joint effect | Genotype | Cases | Controls | OR (95% CI) | P | OR (95% CI)a | P a | P hom | ||
|---|---|---|---|---|---|---|---|---|---|---|
rs12247479 | rs4353229 | GG | CC/CT | 823 (55.4) | 749 (57.6) | 1.00 | 1.00 | 0.076 | ||
TT | 330 (22.2) | 274 (21.1) | 1.10 (0.91–1.32) | 0.340 | 1.07 (0.87–1.30) | 0.532 | ||||
AG/AA | CC/CT | 121 (8.1) | 130 (10.0) | 0.85 (0.65–1.11) | 0.223 | 0.88 (0.67–1.16) | 0.374 | |||
TT | 212 (14.3) | 148 (11.4) | 1.30 (1.03–1.64) | 0.028 | 1.24 (0.97–1.58) | 0.089# | ||||
AG/AA-TT vs. others | 1.29 (1.03–1.62) | 0.026 | 1.23 (0.97–1.55) | 0.091# | ||||||
rs10787498 | rs4353229 | TT | CC/CT | 717 (48.3) | 663 (51.0) | 1.00 | 1.00 | 0.070 | ||
TT | 212 (14.3) | 194 (14.9) | 1.01 (0.81–1.26) | 0.927 | 1.00 (0.79–1.26) | 0.975 | ||||
GT/GG | CC/CT | 227 (15.3) | 216 (16.6) | 0.97 (0.78–1.20) | 0.793 | 1.01 (0.81–1.27) | 0.902 | |||
TT | 330 (22.2) | 228 (17.5) | 1.33 (1.09–1.63) | 0.005 | 1.28 (1.04–1.58) | 0.021 | ||||
GT/GG-TT vs. others | 1.34 (1.11–1.62) | 0.002 | 1.27 (1.04–1.55) | 0.017 | ||||||
rs12247479 | TT | GG | 929 (62.5) | 852 (65.5) | 1.00 | 1.00 | 0.102 | |||
AG/AA | 0 | 5 (0.4) | —— | —— | ||||||
GT/GG | GG | 224 (15.1) | 171 (13.1) | 1.21 (0.97–1.51) | 0.091# | 1.21 (0.97–1.50) | 0.095# | |||
AG/AA | 333 (22.4) | 273 (21.0) | 1.12 (0.93–1.35) | 0.223 | 1.12 (0.93–1.34) | 0.248 | ||||
1–2 putative risk genotypes vs.0 risk genotype | 1.16 (0.99–1.35) | 0.065# | 1.15 (0.98–1.34) | 0.078# | ||||||
rs1127687 | rs4353229 | GG | CC/CT | 675 (45.4) | 629 (48.4) | 1.00 | 1.00 | 0.877 | ||
TT | 221 (14.9) | 175 (13.5) | 1.18 (0.94–1.48) | 0.158 | 1.11 (0.87–1.41) | 0.397 | ||||
AG/AA | CC/CT | 269 (18.1) | 250 (19.2) | 1.00 (0.82–1.23) | 0.980 | 0.99 (0.80–1.23) | 0.911 | |||
TT | 321 (21.6) | 247 (19.0) | 1.21 (0.99–1.47) | 0.063# | 1.17 (0.95–1.44) | 0.149 | ||||
AG/AA-TT vs. others | 1.17 (0.97–1.41) | 0.094# | 1.14 (0.94–1.39) | 0.178 | ||||||
rs12247479 | GG | GG | 655 (44.1) | 578 (44.4) | 1.00 | 1.00 | 0.016 | |||
AG/AA | 241 (16.2) | 226 (17.4) | 0.94 (0.76–1.17) | 0.576 | 0.94 (0.75–1.17) | 0.596 | ||||
AG/AA | GG | 498 (33.5) | 445 (34.2) | 0.99 (0.83–1.17) | 0.885 | 0.98 (0.82–1.17) | 0.833 | |||
AG/AA | 92 (6.2) | 52 (4.0) | 1.56 (1.09–2.23) | 0.015 | 1.48 (1.02–2.15) | 0.040 | ||||
AG/AA-AG/AA vs. others | 1.57 (1.11–2.22) | 0.012 | 1.49 (1.03–2.14) | 0.033 | ||||||
rs10787498 | GG | TT | 498 (33.5) | 451 (34.7) | 1.00 | 1.00 | 0.007 | |||
GT/GG | 398 (26.8) | 353 (27.1) | 1.02 (0.84–1.24) | 0.831 | 1.03 (0.84–1.26) | 0.795 | ||||
AG/AA | TT | 431 (29.0) | 406 (31.2) | 0.96 (0.80–1.16) | 0.678 | 0.96 (0.79–1.17) | 0.680 | |||
GT/GG | 159 (10.7) | 91 (7.0) | 1.58 (1.19–2.11) | 0.002 | 1.52 (1.13–2.06) | 0.006 | ||||
AG/AA-GT/GG vs. others | 1.58 (1.21–2.07) | 0.001 | 1.52 (1.15–2.01) | 0.004 | ||||||
