Figure 5 | Scientific Reports

Figure 5

From: Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

Figure 5

Temporal changes in secondary structures and morphology of α-Syn during amyloid formation.

CD and AFM study of α-Syn during aggregation showing a transition from RC to β-sheet via a helix-rich intermediate. AFM study showing small oligomers/amorphous structures at the beginning, the helix-rich state appears to be composed of a heterogeneous population of different species including spherical oligomers and small filaments before assembled to mature fibrils (at 100 hr). AFM images are squares of 2.5 μm. Heights scales are depicted in individual AFM images.

Back to article page