Figure 4 | Scientific Reports

Figure 4

From: Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Figure 4

Eugenol specifically increases the abundance of the Clostridiaceae 1 and Peptostreptococcaceae families.

(a), Heatmap showing the relative abundance of fecal bacterial OTUs that differed between mice treated with eugenol, metronidazole, combination of both or untreated mice (P < 0.05). Classification scheme: p, phylum; c, class; o, order; f, family; g, genus. (b), Abundances of OTUs that increased with eugenol treatment, including the Clostridiaceae 1 (Eug: **p = 0.0016, Eug vs. Met + Eug: **p = 0.0062), Lachnospiraceae (*p = 0.0127, **p = 0.0043), Peptostreptococcaceae (*p = 0.0127, **p = 0.0043) and Ruminococcaceae (**p = 0.0043) families. Data represented as percent of total OTUs. U = untreated mice. M + E = metronidazole and eugenol treated mice. (c), The miniature phylogeny tree shows the specific families belonging to the Clostridiales order and any relevant genera whose abundance is increased with eugenol treatment. Brackets indicate the classification. (d), Linear regression analysis showing the correlation of mucus thickness with abundance of Clostridiaceae or Peptostreptococcaceae.

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