Figure 4 | Scientific Reports

Figure 4

From: Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice

Figure 4

Transgenerational inheritance of the Kit paramutation phenotype in an intercrossing scheme.

(A) Distribution of the “white-tail-tip” (WTT) phenotype among WT F2s derived from WT WTT F1 mothers intercrossed with WT WTT F1 fathers. (B) Distribution of the WTT phenotype among WT F3s derived from WT WTT F2 mothers intercrossed with WT WTT F2 fathers. (C) Distribution of the WTT phenotype among WT F4s derived from WT WTT F3 mothers intercrossed with WT WTT F3 fathers. (D) Distribution of the WTT phenotype among WT F3s derived from WT WTT F2 mothers intercrossed with WT WTT F2 fathers. Note that the F2 WT WTT parents were derived from outcrossing of WT WTT F1 mothers with WT BTT fathers. (E) Distribution of the WTT phenotype among F3s derived from WT WTT F2 mothers intercrossed with F2 WT WTT fathers. Note that the F2 WT WTT parents were derived from outcrossing of F1 WT WTT (1st WT WTT) fathers with WT BTT mothers. “n” denotes the total number of offspring observed in each of the five mating schemes (A–E).

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