Figure 3
From: Fibronectin localization and fibrillization are affected by the presence of serum in culture media
Morphology of endogenous ED-A FN for HDFs cultured in a serum-containing medium.
The shape is predominantly irregular and featureless; however, independently on the treatment with TGF-β1, areas of partial fibrillization are often recognizable in up to 30–40% of the cells in any given population. The insets show magnified views of these areas In particular the images on the left could be consistent with a pre-fibrillar organization from aligned “spots”; however, we are inclined not to follow this hypothesis, due to the dorsal/ventral differential localization of respectively non-fibrillar and fibrillar FN (see Figure 4).
