Figure 3 | Scientific Reports

Figure 3

From: Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis

Figure 3

Schematic diagram of virus-triggered innate immunity pathway.

DNBs are highlighted in red font and soft blue background. Virus activates RIG-I- or MDA5-mediated activation of NF-κB (not shown) and IRF3 or IRF7, which leads to transcription of the type I interferon (IFN) gene. Type I IFNs induce the expression of ISGF3 complex (consisting of STAT1, STAT2 and IRF9)-mediated IFN-stimulated genes (ISGs), which generates a large number of ISGs and antiviral proteins that can inhibit the viral replication.

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