Figure 1
From: Circulating Peptidome to Indicate the Tumor-resident Proteolysis
A schematic representation of peptidomics analysis for blood biomarkers of tumor activity.
(A) Proteins/peptides are cleaved by proteases within the vicinity of tumor tissues, correlating with tumor growth or response to treatment. These disease-associated proteolytic fragments are released into the bloodstream. (B) Blood/serum samples are processed through on-chip fractionation with nanopore platforms to enrich low-molecular weight peptides. (C) The target biomarkers (proteolytic products of tumor-resident proteases) are detected with mass spectrometry. The specific peptide peaks in the mass spectrum represent the expression and/or activity of their corresponding tumor-resident peptidases.
