Figure 1
From: Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor
Autophagy-related proteins in various forms of labor.
Panels A and B show mRNA expression of Atg4c and Atg7 in uterus and placenta recovered from preterm labor groups and controls. N = 6–11 each group. Panels C and D show tissue distribution of Atg4c and Atg7 protein, respectively. Corresponding immunostaining index scores are shown in E and F [(ISIS) = Stained area score (SAS) X Immunostaining intensity score (IIS)]. Six tissue sections per animal were analyzed. Original magnification: 400X. PBS, LPS and PGN+poly(I:C): intrauterine injections on day 14.5; MIF-C: subcutaneous DMSO control, MIF: subcutaneous mifepristone in DMSO on day 14.5. Error bars = ±SEM. aP ≤ 0.05 Significant difference vs. respective control.
