Figure 1 | Scientific Reports

Figure 1

From: PI3Kβ Inhibitor TGX221 Selectively Inhibits Renal Cell Carcinoma Cells with Both VHL and SETD2 mutations and Links Multiple Pathways

Figure 1

RCC cells with mutated VHL or SETD2 were sensitive to TGX221, reproduced from the Genomics of Drug Sensitivity in Cancer (GDSC) database.

Volcano plotting showing compounds marked in green as sensitive in the setting of RCC cells with (A) VHL gene and (B) SETD2 gene mutations, with TGX221 present in both settings. Scattered plotting showing cells with VHL (C) or SETD2 (D) mutations were all RCC cells. (*P <0.05; **P <0.01)

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