Figure 5 | Scientific Reports

Figure 5

From: PI3Kβ Inhibitor TGX221 Selectively Inhibits Renal Cell Carcinoma Cells with Both VHL and SETD2 mutations and Links Multiple Pathways

Figure 5

TGX221 selectively inhibits cell motility of RCC with mutated VHL and SETD2.

(A) Application of TGX221 in VHL- and SETD2-wildtype HK2 cells and in both mutated A498 RCC cells showing selective inhibition of downstream effectors of VHL, SETD2 and PTEN in A498 cells; (B) Compared with Caki-1 RCC cells that harboured wildtype VHL, TGX221 selectively inhibited the invasiveness and migration in A498 cells; (C) Compared with 786O RCC cells that harboured wildtype SETD2, TGX221 selectively inhibited the invasiveness and migration in A704 cells (*P <0.05; **P <0.01).

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