Table 2 Changes in phosphorylation of proteins in renal clear cell carcinoma with VHL or SETD2 mutation, computed using TCGA KIRC data
Mut. Gene | Tumourigenesis | Target | Average abundance | p-value | Signature | ||
|---|---|---|---|---|---|---|---|
Protein | Residue | Unaltered | Altered | ||||
VHL | anti | CDKN1B | pT157 | 0.18 | −0.18 | 0.0004 | Cell cycle |
anti | CHEK1 | pS345 | 0.12 | −0.19 | 0.0007 | Cell cycle | |
pro | RPS6KA1 | pT359 | 0.17 | −0.07 | 0.0160 | mTOR | |
pro | EIF4EBP1 | pT70 | 0.14 | −0.08 | 0.0360 | mTOR | |
anti | RB1 | pS807 | 0.09 | −0.1 | 0.0490 | Cell cycle | |
pro | EGFR | pY1173 | −0.11 | 0.17 | 0.0060 | EGFR | |
pro | EGFR | pY1068 | −0.08 | 0.17 | 0.0120 | EGFR | |
SETD2 | pro | EIF4EBP1 | pS65 | 0.11 | −0.44 | 0.0000 | mTOR |
pro | PRKCA | pS657 | −0.08 | −0.43 | 0.0005 | MAPK | |
anti | CHEK2 | pT68 | 0.06 | −0.43 | 0.0020 | Cell cycle | |
pro | PRKCD | pS664 | −0.08 | 0.29 | 0.0120 | MAPK | |
pro | YBX1 | pS102 | 0.01 | 0.32 | 0.0350 | EGFR | |
pro | JUN | pS73 | 0.09 | −0.19 | 0.0390 | MAPK | |
pro | RAF1 | pS338 | 0.03 | −0.24 | 0.0410 | MAPK | |
pro | RPS6KB1 | pT389 | 0.02 | −0.19 | 0.0430 | mTOR | |
