Figure 5

Habituation in the hemodynamic response to noxious stimuli on the frontal region.
Comparison of HbO (top, left panels) and HbR changes (bottom, left panels) in response to innocuous and noxious electrical stimuli in the first three minutes (blue) with the HbO and HbR changes in the second three minutes (red). Error bars represent the standard error across subjects (n = 11). Yellow bars show the interval chosen to obtain the mean response depicted for each subject in the scatter plots and stars indicate a statistically significant difference. The right panels show scatter plots comparing the hemodynamic response averaged over the yellow bar during the first and second three minutes for HbO (top) and HbR (bottom). The horizontal green bar shows the stimulus duration.