Figure 4
From: The loss of Tm7sf gene accelerates skin papilloma formation in mice
The lack of Tm7sf2 increases papilloma incidence and multiplicity.
Tm7sf2 WT (n = 15) and KO (n = 15) mice were topically treated with a single dose of DMBA followed by bi-weekly applications of TPA for 19 weeks. (A) H&E staining of 4 μm sections from papillomas of Tm7sf2 WT and KO mice. (B) Papilloma incidence and (C) papilloma multiplicity at the indicated times after DMBA treatment. (D) Representative images of Tm7sf2 WT and KO papilloma-bearing mice (magnification 40×). *p < 0.05 vs control WT mice.
