Figure 1
Spatial training ameliorates hippocampus-dependent memory deficits in Tg2576 mice.
(a) Schematics show experimental procedure: Tg2576 mice received 6 days Morris water maze (MWM) training at ~8 m. Then, the recent and remote memory was retrieved at 24 h or 28 days by contextual fear conditioning. (b–e) Contextual fear conditioning: The freezing response during the fear training (B), the retrieval test of freezing response measured at 24 h after fear training (recent memory) (c), the retrieval test of freezing response measured at 28 days after fear training (remote memory) (d), quantitative analyses of average freezing response over the 3 min session (e). (f) The activity during the initial 3 min exposure to the conditioning chamber. Not trained wild type littermates (N-wt); not trained Tg2576 control mice (N-Tg2576); the trained Tg2576 mice (T-Tg2576). Data were expressed as mean ± SD (n = 10 ~ 12 each group). One-way ANOVA followed by post hoc tests (LSD) was used. *, p < 0.05; **, p < 0.01 vs N-wt; #, p < 0.05; ##, p < 0.01 vs N-Tg576. (c) N-Tg2576 vs N-wt: p1 = 0.002, p2 = 0.004, p3 = 0.023; T-Tg2576 vs N-Tg2576: p1 = 0.006, p2 = 0.007, p3 = 0.030; (d) N-Tg2576 vs N-wt: p1 = 0.033, p2 = 0.006, p3 = 0.002; T-Tg2576 vs N-Tg2576: p1 = 0.012, p2 = 0.031, p3 = 0.001; (e) N-Tg2576 vs N-wt: precent = 0.002, premote = 0.010; T-Tg2576 vs N-Tg2576: precent = 0.039, premote = 0.017.
