Figure 2
From: A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held
A three-pool model underlies rapid and slow RRP replenishment.
(A) The model-predicted RRP replenishment curves with endocytosed vesicles recycling to RP (black), IP (red) and RRP (blue) after a 20 ms depolarisation pulse. The measured data are also plotted for comparison (circle, same as Fig. 1B). The legend also applies to B and C. (B) Similar to A, but with a conditioning stimulus of 10 pulses of 20 ms depolarisation at 10 Hz. (C) Similar to A and B, but with a conditioning stimulus of 10 pulses of 20 ms depolarisation at 1 Hz. (D) The total measured and predicted ΔCm with and without endocytosis induced by 10 pulses of 20 ms depolarisation at 10 Hz (n = 11). (E) The model-predicted (with endocytosis: black curve, without endocytosis: dotted curve) and the measured (circle) ΔCm induced by each depolarising pulse (20 ms depolarisation) during a 10-pulse train at 1 Hz. (F) Similar to D, except that the conditioning stimulus was 10 pulses of 20 ms depolarisation at 1 Hz (n = 6).
