Table 2 Pooled odds ratios for recessive model for the CD24 Ala57Val polymorphism

From: Association between the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythematosus: a meta-analysis

Disease

Variables

No. of studies

Test of association

Test of heterogeneity

OR (95% CI)

P z

P het

I2

MS

Total

6

2.28 (1.68–3.10)

<0.001

0.364

8.1%

 

Subgroup analysis by HWE status

     
 

 Deviation from HWE

2

2.66 (1.59–4.46)

<0.001

0.533

0.0%

 

 No deviation from HWE

4

2.09 (1.42–3.06)

<0.001

0.219

32.2%

 

Subgroup analysis by ethnicity

     
 

 Caucasians

5

2.30 (1.66–3.20)

<0.001

0.247

26.2%

 

  Poser criteriaa

1

1.01 (0.44–2.32)

0.990

NA

NA

 

  McDonald criteriab

4

2.68 (1.86–3.87)

<0.001

0.801

0.0%

SLE

Total

5

1.71 (1.32–2.22)

<0.001

0.188

35.0%

 

Subgroup analysis by ethnicity

     
 

 Caucasians

4

1.71 (1.31–2.24)

<0.001

0.105

51.2%

 

  Subjects ≥ 1000c

1

2.55 (1.57–4.14)

<0.001

NA

NA

 

  Subjects < 1000d

3

1.38 (1.00–1.92)

0.057

0.375

0.0%

  1. CI, confidence interval; HWE, Hardy-Weinberg equilibrium; MS, multiple sclerosis; NA, not available; OR, odds ratio; Phet, P-value for heterogeneity; Pz, P-value for overall effect; SLE, systemic lupus erythematosus.
  2. aCaucasian studies which used Poser criteria.
  3. bCaucasian studies which used McDonald criteria.
  4. cCaucasian studies which included no less than 1000 subjects.
  5. dCaucasian studies which included less than 1000 subjects.
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