Figure 3 | Scientific Reports

Figure 3

From: Increased signaling entropy in cancer requires the scale-free property of proteininteraction networks

Figure 3

Effect of cancer perturbations on signaling entropy:

(A) Examples of two expression perturbations typically found in cancer. Topdepicts the example of an oncogenic hub undergoing overexpression in cancer,which has the effect of drawing in signaling flux from a neighbour i.Example at the bottom depicts the underexpression of a low-degree“tumour suppressor” node (e.g. a transcripton factor),which from the perspective of node i causes, indirectly, an increasedsignaling flux through the nearby hub. (B) Perturbation analysis of the top100 genes ranked according to fold-change between normal and liver cancer.Plots shows the entropy rate after perturbation (y-axis) against node-degree(x-axis), with colors indicating over or underexpression. Black horizontalline defines the entropy rate of the average expression profile of normalliver (i.e. before the perturbation).

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