Table 2 Short term anti-proliferative activity (IC50/μM) for IQc (1, 2a, 2d, 3d, 3e), TMPyP4 and 5-fluorouracil (5-FU) using a panel of human cancera and non-malignantb cell lines

From: KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

 

1

2a

2d

3d

3e

TMPyP4

5-FU

A594c)

 

0.67 (9.3)e

0.40 (12.5)e

 

1.45 (7.0)e

  

ALTc)

 

4.75

1.93

 

7.11

  

MCF7c)

 

2.88

2.40

 

11.40

  

MiaPaCa2c)

 

2.20

  

1.98

  

Panc1c)

 

2.75

0.22

 

4.80

  

HCT116d)

9.91

0.14

0.46

3.46

1.80

12.39

2.38

SW620d)

10.66

0.20

0.59

4.74

1.79

>20

5.39

HEK293Td)

8.03

0.30

0.64

6.57

3.12

2.97

2.66

WI-38c)

 

6.26

4.86

 

10.08

  
  1. a)The panel of cancer cell lines used are: A594 (lung); ALT (telomerase negative human lung fibroblast); MCF7 (breast); MiaPaCa2 (pancreatic); Panc1 (chemo-resistant pancreatic); HCT116 (colon); SW620 (metastatic colon).
  2. b)Non-malignant human cell lines used include: Wi-38 (lung fibroblast); HEK293T (embryonic kidney).
  3. c)Measured by the SRB assay.
  4. d)Measured by the MTS assay.
  5. e)Selectivity index given by: SI = IC50(WI-38)/IC50(A594).
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