Table 2 ACR responsive rate at 24 week and the comparisons between the predictor positive and predictor negative group

From: Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial

Group

ACR 20

ACR 50

ACR 70

  

P+ group

P− group

P+ group

P− group

P+ group

P− group

 

n

Responsive rate n (%)

n

Responsive rate n (%)

n

Responsive rate n (%)

n

Responsive rate n (%)

n

Responsive rate n (%)

n

Responsive rate n (%)

TwHF based therapy group

46

38 (82.6)

51

27 (52.9)

46

26 (56.5)

51

11 (21.6)

46

6 (13.0)

51

6 (11.8)

MTX plus SSZ group

48

31 (64.6)

47

40 (85.1)

48

22 (45.8)

47

28 (59.6)

48

12 (25.0)

47

13 (27.7)

Chi Square

3.91

11.7

1.07

14.75

2.17

3.95

P value

0.048 *

<0.001 *

0.300

<0.001 *

0.141

0.047 *

RR †

RR (TwHF/M&S)

1.2791

0.6221

1.2332

0.362

0.5217

0.4253

95%CI for RR

0.9982–1.639

0.4678–0.8272

0.8279–1.837

0.2039–0.6427

0.2137–1.2739

0.176–1.0279

MH Χ2

3.8678

11.581

1.0625

14.5957

2.1459

3.9136

P value

0.049

<0.001 *

0.303

<0.001 *

0.143

0.048 *

Test of interaction

Z value

3.741

3.4381

0.319

P value

<0.001 *

<0.001 *

0.375

RRR ‡

RRR

2.0563

3.4065

1.2267

95%CI for RRR

1.4095–3

1.6938–6.851

0.3496–4.3038

  1. *P<0.05.
  2. †RR: Relative risks = Responsive rate in TwHF based group/Responsive rate in MTX plus SSZ group.
  3. ‡RRR: Ratio of relative risks = RR in predictor positive group/RR in predictor negative group.
  4. The RR value in predictor positive group based on ACR 20 response = 1.2791 (95% CI: 0.9982–1.639, P = 0.0492), which indicates that in the predictor positive group of patients, the ACR 20 responsive rate of CHM is greater than MTX plus SSZ; the RRR value = 2.0563 > 1, and the 95% CI (1.4095–3) doesn't include 1, which indicate that the ACR 20 responsive rate of TwHF is better in predictor positive group than in predictor negative group.
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