Figure 1 | Scientific Reports

Figure 1

From: Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers

Figure 1

SND1-BRAF transcript fusion in a never smoker lung adenocarcinoma.

(A). Chromosomal rearrangement at 7q32 and 7q34 results in exons 1–9 of SND1 fused to the exon 2 to 3′ end of an inverted BRAF. SND, Staphylococcal nuclease domain; Ex, exon; RBD, Ras-binding domain; CRD, cysteine-rich domain; S/T, serine-threonine. (B). Sequencing traces of the RT-PCR product at fusion junction spanning exon 9 of SND1 (orange) and exon 2 of BRAF (red). The dashed lines show the the reading frame.

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