Figure 6
miR-34a knockdown blocks Sirt7 effects in gastric cancer.
(A) miR-34a knockdown in MGC803 cells. (B) miR-34a knockdown neutralizes the effects of Sirt7 on apoptosis of MGC803 cells. (C) miR-34a knockdown blocks the effects of Sirt7 on DNA damage in MGC803 cells. (D) miR-34a knockdown blocks the effects of Sirt7 on cellular proliferation of MGC803 cells. * p < 0.05, ** p < 0.01, # p < 0.05, ## p < 0.01 vs. LNA-Ctrl+sh-Ctrl. (E) miR-34a knockdown block neutralizes Sirt7 effects on MGC803 cells in vivo. (F) High miR-34a level predicts favorable overall-survival of gastric cancer patients.
