Figure 1 | Scientific Reports

Figure 1

From: The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes

Figure 1

The survivin expression in blood and synovial tissues from RA and OA patients. (a) The serum survivin expression levels were analyzed using an ELISA. (RA, 22 cases; controls, 16 cases) (mean RA, 19.5pg/ml vs. controls, 7.7 pg/ml; p = 0.044). An age- and sex-matched control group consisted of OA and healthy controls (RA, 58.8 ± 15.6 years old; controls, 53.9 ± 19.8 years old; p = 0.404). t-test, *p < 0.05. (b) The survivin expressions in RA and OA synovial tissues were analyzed using IHC (survivin: red, upper sections x40, lower sections x20). The data shown are representative of the samples. Arrows indicate the endothelium of synovia. (c–f) Dual staining in immunohistochemistry for RA synovial tissues. Red pigment and arrows indicate the expression of each lineage marker (CD55; a marker of FLS, CD4; a marker of CD4+ T lymphocytes, CD8; a marker of CD8+ T lymphocytes, MPO (myeloperoxidase); a marker of neutrophil). Green pigment indicates survivin. (x40)

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