Figure 4
From: SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors
SIRT7 regulates metastasis regulatory genes in epithelial and mesenchymal cancer cells.
(A), Western blot analysis showing decreased E-cadherin protein and increased Vimentin levels in SIRT7-deficient PC3 cells (shSIRT7). (B), RT-qPCR analysis showing modulation of E-cadherin, DAB2IP, MMP16 and Slug expression in SIRT7-depleted PC3. (C), RT-qPCR showing decreased expression of MMP16 and VEGF-A in SIRT7 depleted HT1080 cells. Western Blots were carried under same experimental conditions. Uncropped images are available in supplementary figure 1b.
