Figure 6
From: SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors
SIRT7 depletion inhibits lung metastasis in vivo.
(A). Western blot of SIRT7 expression in cells with partial SIRT7 depletion. (B), Tumor volume of subcutaneous xenografts of the SIRT7-depleted and control cells. (C), Effects of SIRT7 depletion on lung metastasis following tail vein injection of immunodeficient mice with control (shcontrol) or SIRT7-depleted (shSIRT7-1, shSIRT7-2) cells. Non-Injected Control (NIC): normal lungs. *, ** indicate significant differences between the sh-control and shSIRT7 groups by Welch's T test (**: P < 0.005, *: P < 0.05). # indicates significant difference between the no injection control lungs and the sh-control HT1080-injected group (P < 0.005). ns, non-specific band.
